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Symbol Name ID |
Tbk1
TANK-binding kinase 1 MGI:1929658 |
| Darker colors indicate more annotations |
| Mouse Phenotypes | increased spleen weight |
abnormal class switch recombination |
decreased basophil cell number |
decreased eosinophil cell number |
increased mature B cell number |
decreased NK T cell number |
increased NK T cell number |
increased monocyte cell number |
abnormal B cell physiology |
increased IgA level |
increased IgM level |
abnormal macrophage physiology |
increased circulating interleukin-1 beta level |
increased circulating interleukin-10 level |
increased circulating interleukin-6 level |
increased circulating tumor necrosis factor level |
abnormal cytokine level |
lymphoid hyperplasia |
abnormal cytokine secretion |
abnormal interferon secretion |
decreased interferon-beta secretion |
increased interleukin-6 secretion |
increased tumor necrosis factor secretion |
increased anti-nuclear antigen antibody level |
increased anti-double stranded DNA antibody level |
abnormal inflammatory response |
increased susceptibility to endotoxin shock |
skin inflammation |
increased susceptibility to bacterial infection induced morbidity/mortality |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Tbk1tm1.1Lex/Tbk1tm1.1Lex | ||||||||||||||||||||||||||||||
| Tbk1M1Btlr/Tbk1+ | ||||||||||||||||||||||||||||||
| Tbk1tm1.1Lex/Tbk1+ | ||||||||||||||||||||||||||||||
| Tbk1tm1Arte/Tbk1tm1Arte Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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